Australia, Britain, Canada, New Zealand, South Africa, and the United States used the Beaufighter Mk VIs.
Royal Air Force (RAF) squadrons with Beaufighter Mk VIs were located in Cyprus, India, Malta, North Africa, and Sardinia.
Fourteen RAF night fighter squadrons were equipped with the Beaufighter Mk VIF. These were used until 1944 when they were replaced by Mosquitos.
In the Mediterranean four USAAF squadrons were equipped with the Beaufighter Mk VIF.
On April 30, 1943, off Setif, Fight Sergeant Downing and Sergeant Lyons shot down five Junkers Ju 52/3m transports within 10 minutes.
- United Kingdom: No 29, No 68, No 96, No 125, No 141, No 153, No 219, No 255, No 256, No 272, No 307, No 600, No 604
- Middle East: No 46, No 89, No 108, No 144, No 252
- Far East: No 27, No 89, No 176, No 177
Coastal Command used the Beaufighter Mk VIC in Strike Wings. They were used on the coasts of Western Europe and up to Norway.
From April 1943 the Beaufighter Mk VICs were used in operations equipped with a torpedo. In May 1943 they could be equipped with rockets.
In the Far East the Japanese nicknamed the Beaufighters the "Whispering Death" because of the nose its engines made.