First deliveries of the Re.2002 went to the 5° Stormo in March 1942 and these became operational in July 1943. These were used against the Allies invading Sicily.
In July 1943 the 101°, at Lonate Pozzolo, and 102°, at Tarquinia, Guppi Assalto were equipped with the Re.2002.
After Italy's surrender the Germans took over around 60 of the Re.2002s. Many of these were used in France against the Maquis.
Around 40 of the Re.2002s were used with the Allied forces until mid 1944.