Italy and Germany used the P.108. The Piaggio P.108 was the only four engine heavy bomber used by the Regia Aeronautica.
As pilots and crew were unaccustomed to the style of aircraft there were several accidents with the first operational squadron.
The 274a Squadriglia Auronoma Gombardamento a Grande Raggio (B.R.G.) received the pre-production P.108Bs.
The P.108's first mission was on June 9, 1942. It was a search and bomb naval mission near the Balearic Islands.
The P.108 was used in attacking Gibraltar in early 1942 at night.
Benito Mussolini's son Bruno was killed in a P.108 while attacking Gibraltar.
Some P.108s were used on the Eastern Front.
In the Mediterranean the P.108s were used against Allied convoys.
The Germans captured around 17 P.108s when Italy surrendered. They were not used on combat missions. Some were used in the evacuation of the Crimea carrying up to 125 evacuees each.