Italy and Germany used the P.108.
As pilots and crew were unaccustomed to the style of aircraft there were several accidents with the first operational squadron.
The P.108's first mission was on June 9, 1942. It was a search and bomb naval mission near the Balearic Islands.
The P.108 was used in attacking Gibraltar in early 1942 at night.
Benito Mussolini's son Bruno was killed in a P.108 while attacking Gibralter.
Some P.108s were used on the Eastern Front.
In the Mediterranean the P.108s were used against Allied convoys.
The Germans captured around 17 P.108s when Italy surrendered. They were not used on combat missions.